Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity. |
In vitro | MTH1 is an inhibitors ?and for use in the treatment or prevention of cancer.The enzyme human MTH1 is a 2-hydroxy-dATP diphosphatase.?MTH1 specifically assists RAS-induced tumors in preventing tumor- suppressive effects such as senescence whilst enabling maintenance and progression of the tumor.?MTH1 inhibition helps impairing tumor growth by abrogating mitogenic signaling, epithelial-mesenchymal transition (EMT), a hallmark of progressing and aggressive tumors, anoikis inhibition and PI3K/Akt-mediated pro-survival signaling.?MTH1 inhibitors induce oxidative DNA lesions[1]. |
Molecular Weight | 469.55 |
Formula | C24H27N3O5S |
CAS No. | 901044-91-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MTH1-IN-2 901044-91-5 DNA Damage/DNA Repair MTH1 MTH1IN2 MTH-1-IN-2 MTH1 IN 2 inhibitor inhibit