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MTH1-IN-2
Catalog No. T12122Cas No. 901044-91-5
MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.
MTH1-IN-2
Catalog No. T12122Cas No. 901044-91-5
MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity. |
| In vitro | MTH1 is an inhibitors ?and for use in the treatment or prevention of cancer.The enzyme human MTH1 is a 2-hydroxy-dATP diphosphatase.?MTH1 specifically assists RAS-induced tumors in preventing tumor- suppressive effects such as senescence whilst enabling maintenance and progression of the tumor.?MTH1 inhibition helps impairing tumor growth by abrogating mitogenic signaling, epithelial-mesenchymal transition (EMT), a hallmark of progressing and aggressive tumors, anoikis inhibition and PI3K/Akt-mediated pro-survival signaling.?MTH1 inhibitors induce oxidative DNA lesions[1]. |
| Molecular Weight | 469.55 |
| Formula | C24H27N3O5S |
| Cas No. | 901044-91-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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