Shopping Cart
- Remove All
- Your shopping cart is currently empty
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $31 | In Stock | |
2 mg | $41 | In Stock | |
5 mg | $66 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $198 | In Stock | |
50 mg | $386 | In Stock | |
100 mg | $573 | In Stock | |
1 mL x 10 mM (in DMSO) | $72 | In Stock |
Description | TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16. |
Targets&IC50 | MTH1:0.8 nM |
In vitro | TH287 selectively and effectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells, and induces oxidative DNA damage. [1] |
In vivo | In C57Bl/6 mice, TH287 (5 mk/kg, i.p.) causes a peak time and maximum concentration of 0.5 h and 0.82 μM. [2] |
Molecular Weight | 269.13 |
Formula | C11H10Cl2N4 |
Cas No. | 1609960-30-6 |
Smiles | CNc1cc(nc(N)n1)-c1cccc(Cl)c1Cl |
Relative Density. | 1.440 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 10 mg/mL (37.15 mM), Heating is recommended. DMSO: 49 mg/mL (160.3 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.