Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

TH287

🥰Excellent
Catalog No. T2069Cas No. 1609960-30-6

TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.

TH287

TH287

🥰Excellent
Purity: 99%
Catalog No. T2069Cas No. 1609960-30-6
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
2 mg$41In Stock
5 mg$66In Stock
10 mg$97In Stock
25 mg$198In Stock
50 mg$386In Stock
100 mg$573In Stock
1 mL x 10 mM (in DMSO)$72In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "TH287"

Select Batch
Purity:99%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
Targets&IC50
MTH1:0.8 nM
In vitro
TH287 selectively and effectively kill U2OS and other cancer cell lines with less toxic to several primary or immortalized cells, and induces oxidative DNA damage. [1]
In vivo
In C57Bl/6 mice, TH287 (5 mk/kg, i.p.) causes a peak time and maximum concentration of 0.5 h and 0.82 μM. [2]
Chemical Properties
Molecular Weight269.13
FormulaC11H10Cl2N4
Cas No.1609960-30-6
SmilesCNc1cc(nc(N)n1)-c1cccc(Cl)c1Cl
Relative Density.1.440 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 10 mg/mL (37.15 mM), Heating is recommended.
DMSO: 49 mg/mL (160.3 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.7157 mL18.5784 mL37.1568 mL185.7838 mL
5 mM0.7431 mL3.7157 mL7.4314 mL37.1568 mL
10 mM0.3716 mL1.8578 mL3.7157 mL18.5784 mL
20 mM0.1858 mL0.9289 mL1.8578 mL9.2892 mL
DMSO
1mg5mg10mg50mg
50 mM0.0743 mL0.3716 mL0.7431 mL3.7157 mL
100 mM0.0372 mL0.1858 mL0.3716 mL1.8578 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy TH287 | purchase TH287 | TH287 cost | order TH287 | TH287 chemical structure | TH287 in vivo | TH287 in vitro | TH287 formula | TH287 molecular weight