Shopping Cart

Remove All

Your shopping cart is currently empty

TH287 hydrochloride

Select Batch

Purity:99.5%

Resource Download

COA LCMS HPLC HNMR

TH287 hydrochloride

Catalog No. T2069LCas No. 1638211-05-8

TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$46	In Stock
2 mg	$64	In Stock
5 mg	$92	In Stock
10 mg	$139	In Stock
25 mg	$251	In Stock
50 mg	$375	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "TH287 hydrochloride"

Product Introduction

Bioactivity

Description	TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
Targets&IC50	MTH1:0.8 nM
In vitro	TH287 as first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 protein in cells.?Protein co-crystal structures demonstrate that the inhibitors bind in the active site of MTH1.?The inhibitors cause incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts[1].

Chemical Properties

Molecular Weight	305.59
Formula	C11H11Cl3N4
Cas No.	1638211-05-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 27.5 mg/mL (89.99 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2724 mL	16.3618 mL	32.7236 mL	163.6179 mL
5 mM	0.6545 mL	3.2724 mL	6.5447 mL	32.7236 mL
10 mM	0.3272 mL	1.6362 mL	3.2724 mL	16.3618 mL
20 mM	0.1636 mL	0.8181 mL	1.6362 mL	8.1809 mL
50 mM	0.0654 mL	0.3272 mL	0.6545 mL	3.2724 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc