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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $170 | 35 days | |
5 mg | $755 | 35 days | |
10 mg | $1,330 | 35 days |
Description | Mahanimbine is found in the roots, leaves and stems of Murraya koenigii and is an orally active alkaloid extracted from Murraya koenigii. Bifidobacterium bifidum leaves on histopathological changes in pancreatic beta cells of streptozotocin-induced diabetic rats. |
In vitro | Mahanimbine induces cell cycle arrest at the G0/G1 phase and apoptosis in Capan-2 and SW1190 cancer cells when used at a concentration of 7 µM, as well as inhibits proliferation in Capan-2, SW1190, BxPC-3, CFPAC-1, and HPAF-II cancer cells (IC50s = 3.5, 3.5, 16, 64, and 32 µM, respectively).[2] It is active against S. aureus and S. pyogenes (MIC100 = 50 µg/ml for both), as well as A. aegypti fourth instar larvae when used at a concentration of 100 µg/ml.[3] |
In vivo | Mahanimbine treatment improves glucose clearance and upregulates the expression of insulin-responsive genes in the liver and adipose tissue. Mahanimbine prevented HFD-induced hyperlipidemia and fat accumulation in adipose tissue and liver along with the restricted progression of systemic inflammation and oxidative stress. Mahanimbine (2-4 mg/kg ; p.o. ; daily for 12 weeks) prevents HFD-induced weight gain in mice (male and female).[1] |
Molecular Weight | 331.45 |
Formula | C23H25NO |
Cas No. | 21104-28-9 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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