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Melflufen hydrochloride

Name: Melflufen hydrochloride
Brand: TargetMol
SKU: T40478
Price: 142 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T40478Cas No. 380449-54-7

Alias Melphalan flufenamide hydrochloride, Melflufen hydrochloride

Melflufen (Melphalan flufenamide) hydrochloride, an alkylating agent and dipeptide prodrug of Melphalan, exhibits antitumor activity by inducing irreversible DNA damage and cytotoxicity in multiple myeloma (MM) cells, while also inhibiting angiogenesis.

Melflufen hydrochloride

😃Good

Catalog No. T40478Alias Melphalan flufenamide hydrochloride, Melflufen hydrochlorideCas No. 380449-54-7

Pack Size	Price	Availability	Quantity
5 mg	$378	7-10 days

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Product Introduction

Bioactivity

Description	Melflufen (Melphalan flufenamide) hydrochloride, an alkylating agent and dipeptide prodrug of Melphalan, exhibits antitumor activity by inducing irreversible DNA damage and cytotoxicity in multiple myeloma (MM) cells, while also inhibiting angiogenesis.
In vitro	Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM; 24 hours) significantly reduces the viability of multiple myeloma cells (MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, ANBL-6) in a concentration-dependent manner, induces apoptosis in MM.1S cells, and potently activates exosome secretion[1][3].
In vivo	Melflufen (Melphalan flufenamide) hydrochloride, administered intravenously at a dosage of 3 mg/kg twice weekly for two weeks, demonstrates significant anti-multiple myeloma (MM) activity in a human plasmacytoma MM.1S xenograft mouse model using CB-17 SCID mice. This treatment notably inhibited MM tumor growth and extended the survival of the mice.
Alias	Melphalan flufenamide hydrochloride, Melflufen hydrochloride

Chemical Properties

Molecular Weight	534.88
Formula	C₂₄H₃₁Cl₃FN₃O₃
Cas No.	380449-54-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

Melflufen HydrochlorideMelphalan flufenamide Hydrochloride