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N-Me-N-bis-PEG3

Catalog No. T18441Cas No. 342818-95-5

N-Me-N-bis-PEG3 is a PEG-based linker for PROTACs, facilitating the joining of two essential ligands crucial for PROTAC molecule formation. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

N-Me-N-bis-PEG3

N-Me-N-bis-PEG3

Catalog No. T18441Cas No. 342818-95-5
N-Me-N-bis-PEG3 is a PEG-based linker for PROTACs, facilitating the joining of two essential ligands crucial for PROTAC molecule formation. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
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Product Introduction

Bioactivity
Description
N-Me-N-bis-PEG3 is a PEG-based linker for PROTACs, facilitating the joining of two essential ligands crucial for PROTAC molecule formation. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
In vitro
PROTACs encompass two distinct ligands connected by a linker: one ligand targets an E3 ubiquitin ligase, and the other binds to the target protein. They leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins[1].
Chemical Properties
Molecular Weight295.37
FormulaC13H29NO6
Cas No.342818-95-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

N Me N bis PEG3N-Me-N-bis-PEG3N-Me-N-bis-PEG-3NMeNbisPEG3
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