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NSC 109555 is a selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $63 | 35 days | |
5 mg | $210 | 35 days | |
10 mg | $350 | 35 days | |
50 mg | $1,300 | 35 days |
Description | NSC 109555 is a selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo. |
Alias | NSC-109555, NSC109555, DDUG diMS, DDUG dimethanesulfonate |
Molecular Weight | 600.67 |
Formula | C21H32N10O7S2 |
Cas No. | 15427-93-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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