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Nicodicosapent

Name: Nicodicosapent
Brand: TargetMol
SKU: T16322
Price: 43 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T16322Cas No. 1269181-69-2

Nicodicosapent is a fatty acid niacin conjugate and an inhibitor of the sterol regulatory element-binding protein (SREBP), which is a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

Nicodicosapent

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Catalog No. T16322Cas No. 1269181-69-2

Pack Size	Price	Availability
2 mg	$94	5 days
25 mg	$690	6-8 weeks
50 mg	$897	6-8 weeks
100 mg	$1,490	6-8 weeks

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Product Introduction

Bioactivity

Description	Nicodicosapent is a fatty acid niacin conjugate and an inhibitor of the sterol regulatory element-binding protein (SREBP), which is a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.
In vitro	Nicodicosapent obviously suppresses ApoB secretion in a dose-dependent manner (IC50: 27 μM). Nicodicosapent displays a synergistic inhibition on secreted PCSK9 ( IC50: 17 μM). Nicodicosapent reduces the production of mature SREBP-2 protein in HepG2 cells but does not interact with the GPR109A receptor. Nicodicosapent causes time-dependent hydrolysis in HepG2 cells.
In vivo	Nicodicosapent (100 mg/kg p.o.) produces high plasma levels of nicotinic acid in the plasma. ApoE*3-Leiden mice treated with Nicodicosapent display an obvious reduction in PCSK9 levels, LDL particles including VLDL and LDL cholesterol, and plasma triglycerides.

Chemical Properties

Molecular Weight	449.63
Formula	C₂₈H₃₉N₃O₂
Cas No.	1269181-69-2
Relative Density.	1.013 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (222.41 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2241 mL	11.1203 mL	22.2405 mL	111.2025 mL
5 mM	0.4448 mL	2.2241 mL	4.4481 mL	22.2405 mL
10 mM	0.2224 mL	1.1120 mL	2.2241 mL	11.1203 mL
20 mM	0.1112 mL	0.5560 mL	1.1120 mL	5.5601 mL
50 mM	0.0445 mL	0.2224 mL	0.4448 mL	2.2241 mL
100 mM	0.0222 mL	0.1112 mL	0.2224 mL	1.1120 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Nicodicosapent