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Nigericin
🥰Excellent
Catalog No. T16323Cas No. 28380-24-7
Nigericin, an antibiotic derived from Streptomyces hygroscopicus, acts as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. It can activate NLRP3 and cause the release of IL-1β in a NALP3-dependent manner. Nigericin induces eryptosis, partly due to oxidative stress and ROS formation, and also causes apoptosis.
Nigericin
🥰Excellent
Catalog No. T16323Cas No. 28380-24-7
Nigericin, an antibiotic derived from Streptomyces hygroscopicus, acts as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. It can activate NLRP3 and cause the release of IL-1β in a NALP3-dependent manner. Nigericin induces eryptosis, partly due to oxidative stress and ROS formation, and also causes apoptosis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $34 | In Stock | |
| 5 mg | $77 | In Stock | |
| 10 mg | $129 | In Stock | |
| 25 mg | $277 | In Stock | |
| 50 mg | $450 | In Stock | |
| 100 mg | $723 | In Stock | |
| 200 mg | $996 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Nigericin, an antibiotic derived from Streptomyces hygroscopicus, acts as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. It can activate NLRP3 and cause the release of IL-1β in a NALP3-dependent manner. Nigericin induces eryptosis, partly due to oxidative stress and ROS formation, and also causes apoptosis. |
| Molecular Weight | 724.96 |
| Formula | C40H68O11 |
| Cas No. | 28380-24-7 |
| Relative Density. | 1.19 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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