Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Olcegepant hydrochloride is a potent and selective non-peptidethe calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (with IC50 of 0.03 nM for human CGRP).
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50 mg | Inquiry | $ 813.00 |
Description | Olcegepant hydrochloride is a potent and selective non-peptidethe calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (with IC50 of 0.03 nM for human CGRP). |
Targets&IC50 | CGRP1:0.03 nM , CGRP (human):(ki)14.4 pM |
In vitro | Olcegepant (BIBN4096BS) is extremely potent at primate CGRP receptors exhibiting an affinity (Ki) for human CGRP receptors of 14.4±6.3 (n=4) pM[2].?Several lines of evidence suggest that a calcitonin-gene related peptide (CGRP) receptor antagonist may serve as a novel abortive migraine treatment.?Olcegepant (BIBN4096BS) exhibits competitive antagonism at the CGRP receptor present in SK-N-MC cells.?Isolated human cerebral, coronary, and omental arteries are studied with a sensitive myograph technique.?CGRP induces a concentration-dependent relaxation that is antagonized by Olcegepant in a competitive manner[3]. |
In vivo | Pre-treatment with Olcegepant (900 μg/kg) inhibits the capsaicin-induced expression of Fos throughout the spinal trigeminal nucleus by 57%.?In contrast, the expression of phosphorylated extracellular signal-regulated kinase in the trigeminal ganglion is not changed by Olcegepant pre-treatment[4]. |
Synonyms | BIBN-4096 hydrochloride, BIBN4096BS hydrochloride |
Molecular Weight | 906.11 |
Formula | C38H48Br2ClN9O5 |
CAS No. | 586368-06-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 66.66 mg/mL (73.57 mM)
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Olcegepant hydrochloride 586368-06-1 Others BIBN4096 Hydrochloride BIBN-4096 hydrochloride BIBN4096BS hydrochloride BIBN4096BS Hydrochloride BIBN-4096 Hydrochloride Olcegepant Hydrochloride BIBN 4096 Hydrochloride inhibitor inhibit