Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in the lung fibrosis model. PAT-048 has an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,670.00 | |
50 mg | 6-8 weeks | $ 2,180.00 | |
100 mg | 6-8 weeks | $ 2,800.00 |
Description | PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in the lung fibrosis model. PAT-048 has an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma. |
Targets&IC50 | ATX (mouse plasma): 200 nM(IC90), ATX (mouse plasma):20 nM |
Molecular Weight | 461.91 |
Formula | C22H18ClF2N3O2S |
CAS No. | 1359983-15-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PAT-048 1359983-15-5 Metabolism PDE PAT 048 PAT048 inhibitor inhibit