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PEG5-bis-(Ethyl phosphonate)

Catalog No. T16461Cas No. 1446282-28-5

PEG5-bis-(Ethyl phosphonate) is a polyethylene glycol (PEG) derived PROTAC linker used in PROTAC synthesis [1].

PEG5-bis-(Ethyl phosphonate)

PEG5-bis-(Ethyl phosphonate)

Catalog No. T16461Cas No. 1446282-28-5
PEG5-bis-(Ethyl phosphonate) is a polyethylene glycol (PEG) derived PROTAC linker used in PROTAC synthesis [1].
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Product Introduction

Bioactivity
Description
PEG5-bis-(Ethyl phosphonate) is a polyethylene glycol (PEG) derived PROTAC linker used in PROTAC synthesis [1].
In vitro
PROTACs consist of two ligands linked together: one ligand targets an E3 ubiquitin ligase, while the other targets the desired protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade specific proteins[1].
Chemical Properties
Molecular Weight522.5
FormulaC20H44O11P2
Cas No.1446282-28-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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