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PF-06471553

Name: PF-06471553
Brand: TargetMol
SKU: T16494
Price: 140 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. T16494Cas No. 1808094-07-6

PF-06471553 is an effective and selective inhibitor of monoacylglycerol acyltransferase 3 (IC50: 92 nM).

PF-06471553

Catalog No. T16494Cas No. 1808094-07-6

PF-06471553 is an effective and selective inhibitor of monoacylglycerol acyltransferase 3 (IC50: 92 nM).

Pack Size	Price	Availability
25 mg	$1,450	6-8 weeks
50 mg	$1,890	6-8 weeks
100 mg	$2,800	6-8 weeks

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Product Introduction

Bioactivity

Description	PF-06471553 is an effective and selective inhibitor of monoacylglycerol acyltransferase 3 (IC50: 92 nM).
Targets&IC50	MGAT3:92 nM
In vitro	PF-06471553 shows inhibitory activity against MGAT3 in HEK-293 cells with an IC50 of 205 nM (pIC50, 6.69). PF-06471553 displays >160 fold in vitro selectivity for MGAT3 over DGAT1 (IC50, >50 μM), DGAT2 (IC50, >100 μM), MGAT1 (IC50, 14.9 μM), and MGAT2 (IC50, 19.8 μM) [1].
In vivo	In hMGAT3 mice, PF-06471553 (200 mg/kg, p.o.) in addition to (DGAT1 and DGAT2) inhibitors display additional inhibition of glycerol-d5 incorporated triolein. It has no effect on WT mice[1].

Chemical Properties

Molecular Weight	467.54
Formula	C₂₃H₂₅N₅O₄S
Cas No.	1808094-07-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 150 mg/mL (320.83 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1389 mL	10.6943 mL	21.3885 mL	106.9427 mL
5 mM	0.4278 mL	2.1389 mL	4.2777 mL	21.3885 mL
10 mM	0.2139 mL	1.0694 mL	2.1389 mL	10.6943 mL
20 mM	0.1069 mL	0.5347 mL	1.0694 mL	5.3471 mL
50 mM	0.0428 mL	0.2139 mL	0.4278 mL	2.1389 mL
100 mM	0.0214 mL	0.1069 mL	0.2139 mL	1.0694 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PF-06471553PF 06471553PF06471553