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PSI-7409

Name: PSI-7409
Brand: TargetMol
SKU: T12572
Rating: 4.5 (1 reviews)

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Catalog No. T12572Cas No. 1015073-42-3

PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).

PSI-7409

😃Good

Catalog No. T12572Cas No. 1015073-42-3

PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).

Pack Size	Price	Availability	Quantity
25 mg	$1,520	Backorder

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).
In vitro	The active triphosphate, PSI-7409, inhibited recombinant NS5B polymerases from genotypes 1 to 4 with comparable 50% inhibitory concentrations.?PSI-7409 also lacked any significant activity against cellular DNA and RNA polymerases.?No cytotoxicity, mitochondrial toxicity, or bone marrow toxicity was associated with PSI-7851 at the highest concentration tested (100 microM)[1].

Chemical Properties

Molecular Weight	500.16
Formula	C₁₀H₁₆FN₂O₁₄P₃
Cas No.	1015073-42-3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 50 mg/mL (99.97 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.9994 mL	9.9968 mL	19.9936 mL	99.9680 mL
5 mM	0.3999 mL	1.9994 mL	3.9987 mL	19.9936 mL
10 mM	0.1999 mL	0.9997 mL	1.9994 mL	9.9968 mL
20 mM	0.1000 mL	0.4998 mL	0.9997 mL	4.9984 mL
50 mM	0.0400 mL	0.1999 mL	0.3999 mL	1.9994 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PSI 7409PSI-7409PSI7409