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PSI-7409 tetrasodium

Name: PSI-7409 tetrasodium
Brand: TargetMol
SKU: T13852
Price: 37 EUR
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T13852Cas No. 1621884-22-7

PSI-7409 tetrasodium, the active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), exhibits specific inhibitory activity against NS5B polymerases of various genotypes, with IC50s being 1.6 μM for GT 1b_Con1, 2.8 μM for GT 2a_JFH1, 0.7 μM for GT 3a, and 2.6 μM for GT 4a, respectively.

PSI-7409 tetrasodium

😃Good

Catalog No. T13852Cas No. 1621884-22-7

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	PSI-7409 tetrasodium, the active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), exhibits specific inhibitory activity against NS5B polymerases of various genotypes, with IC50s being 1.6 μM for GT 1b_Con1, 2.8 μM for GT 2a_JFH1, 0.7 μM for GT 3a, and 2.6 μM for GT 4a, respectively.
Targets&IC50	GT2a JFH1:2.8 μM , GT3a:0.7 μM , GT4a:2.6 μM , GT1b Con1:1.6 μM
In vitro	The active triphosphate, PSI-7409, inhibited recombinant NS5B polymerases from genotypes 1 to 4 with comparable 50% inhibitory concentrations.?PSI-7409 also lacked any significant activity against cellular DNA and RNA polymerases.?No cytotoxicity, mitochondrial toxicity, or bone marrow toxicity was associated with PSI-7851 at the highest concentration tested (100 microM)[1].

Chemical Properties

Molecular Weight	592.117
Formula	C₁₀H₁₆FN₂Na₄O₁₄P₃
Cas No.	1621884-22-7
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 125 mg/mL (211.11 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.6889 mL	8.4443 mL	16.8886 mL	84.4428 mL
5 mM	0.3378 mL	1.6889 mL	3.3777 mL	16.8886 mL
10 mM	0.1689 mL	0.8444 mL	1.6889 mL	8.4443 mL
20 mM	0.0844 mL	0.4222 mL	0.8444 mL	4.2221 mL
50 mM	0.0338 mL	0.1689 mL	0.3378 mL	1.6889 mL
100 mM	0.0169 mL	0.0844 mL	0.1689 mL	0.8444 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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