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SGD-1882

SGD-1882
SGD-1882 (PBD dimer) is a cytotoxic conjugate that is a target for mouse and human hematopoietic stem cells (HSC) and acute myeloid leukemia cells.
Catalog No. T19560Cas No. 1222490-34-7
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SGD-1882

Catalog No. T19560Alias PBD dimer, SGD1882Cas No. 1222490-34-7

SGD-1882 (PBD dimer) is a cytotoxic conjugate that is a target for mouse and human hematopoietic stem cells (HSC) and acute myeloid leukemia cells.
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1 mg$2,3907-10 days
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Product Introduction

Bioactivity
Description
SGD-1882 (PBD dimer) is a cytotoxic conjugate that is a target for mouse and human hematopoietic stem cells (HSC) and acute myeloid leukemia cells.
In vitro
SGD-1882 is not an MDR1 substrate, and SGN-CD33A is conjugated to the SGD-1882. SGN-CD33A can kill MDR1 expressing CD33 positive AML patient samples and is currently in Phase I. [2]
AliasPBD dimer, SGD1882
Chemical Properties
Molecular Weight725.79
FormulaC42H39N5O7
Cas No.1222490-34-7
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (110.22 mM.), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3778 mL6.8890 mL13.7781 mL68.8905 mL
5 mM0.2756 mL1.3778 mL2.7556 mL13.7781 mL
10 mM0.1378 mL0.6889 mL1.3778 mL6.8890 mL
20 mM0.0689 mL0.3445 mL0.6889 mL3.4445 mL
50 mM0.0276 mL0.1378 mL0.2756 mL1.3778 mL
100 mM0.0138 mL0.0689 mL0.1378 mL0.6889 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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