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SP-96

SP-96
SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negative breast cancer studies.
Catalog No. T41256Cas No. 2682114-54-9
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Purity:99.52%
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SP-96

Catalog No. T41256Cas No. 2682114-54-9
SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negative breast cancer studies.
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Pack SizePriceAvailabilityQuantity
1 mg$67In Stock
5 mg$163In Stock
10 mg$263In Stock
25 mg$513In Stock
50 mg$747In Stock
100 mg$1,050In Stock
1 mL x 10 mM (in DMSO)$178In Stock
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Product Introduction

Bioactivity
Description
SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth inhibition in NCI60 screening, including MDA-MD-468 (GI50=107 nM). SP-96 can be used in triple negative breast cancer studies.
Targets&IC50
Aurora A:18.975 nM, Aurora B:0.316 nM
In vitro
SP-96 (63.2 nM) inhibits Aurora B activity in H460 cells by the characteristics of increased DNA content, and it increases cell volume with enormous nucleus. SP-96 shows >2000 fold selectivity against FLT3 (IC50=1475.6 nM) and KIT (IC50=1307.6 nM). SP-96 (0-2 µM) inhibits Aurora A with IC50 value of 18.975 nM. SP-96 (0-1 µM; 24 hours) is not promiscuous, rather selective for a few cell lines, it inhibits MDA-MB-468, CCRF-CEM, COLO 205 and A498 cell growth with GI50 values of 107 nM,47.4 nM, 50.3 nM and 53.2 nM, respectively[1].
Chemical Properties
Molecular Weight453.47
FormulaC25H20FN7O
Cas No.2682114-54-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 95 mg/mL (209.50 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2052 mL11.0261 mL22.0522 mL110.2609 mL
5 mM0.4410 mL2.2052 mL4.4104 mL22.0522 mL
10 mM0.2205 mL1.1026 mL2.2052 mL11.0261 mL
20 mM0.1103 mL0.5513 mL1.1026 mL5.5130 mL
50 mM0.0441 mL0.2205 mL0.4410 mL2.2052 mL
100 mM0.0221 mL0.1103 mL0.2205 mL1.1026 mL

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