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ST4206
Catalog No. T14015Cas No. 1246018-36-9
ST4206 is an antagonist of adenosine A2A. For adenosine A2A receptor and adenosine A1 receptor, the Kis values are 12 nM and 197 nM , respectively.
ST4206
Catalog No. T14015Cas No. 1246018-36-9
ST4206 is an antagonist of adenosine A2A. For adenosine A2A receptor and adenosine A1 receptor, the Kis values are 12 nM and 197 nM , respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ST4206 is an antagonist of adenosine A2A. For adenosine A2A receptor and adenosine A1 receptor, the Kis values are 12 nM and 197 nM , respectively. |
| Targets&IC50 | A2A receptor:（ki）12 nM, A1 receptor:197 nM（ki） |
| In vitro | ST4206 inhibits agonist-induced cAMP accumulation with an IC50 of 990 nM [1]. |
| In vivo | ST4206, administered orally at doses of 10, 20, and 40 mg/kg, counteracts haloperidol-induced catalepsy and enhances motor activity in mice in a dose-dependent fashion. At dosages of 20 and 40 mg/kg, the compound markedly augments the number of contralateral turns in rats triggered by l-DOPA[1]. Demonstrating oral efficacy at concentrations of 10, 20, and 40 mg/kg, ST4206 effectively mitigates haloperidol-induced catalepsy in mice[2]. |
| Molecular Weight | 286.29 |
| Formula | C12H14N8O |
| Cas No. | 1246018-36-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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