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Sardomozide
Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC)(IC50 of 5 nM).
Catalog No. T12833Cas No. 149400-88-4
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Sardomozide
Catalog No. T12833Alias CGP 48664, SAM-486ACas No. 149400-88-4
Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC)(IC50 of 5 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 1-2 weeks | |
| 50 mg | $1,980 | 1-2 weeks | |
| 100 mg | $2,500 | 1-2 weeks |
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Bioactivity
Chemical Properties
| Description | Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC)(IC50 of 5 nM). |
| Targets&IC50 | SAMDC:5 nM |
| In vitro | Sardomozide acts as an inhibitor of S-adenosylmethionine decarboxylase (SAMDC), showing potency with an IC50 value of 5 nM in cell assays. With a 48-hour exposure to 3 μM of Sardomozide, the activity of intracellular SAMDC is diminished to 10% compared to the control[1]. Additionally, in cells grown in the presence of Sardomozide, specifically CHO/664 cells treated with DENSPM, there is an absence of vacuole formation. These cells also exhibit inhibited growth and maintain DENSPM levels comparable to those in parental CHO cells[2]. |
| Alias | CGP 48664, SAM-486A |
| Molecular Weight | 230.27 |
| Formula | C11H14N6 |
| Cas No. | 149400-88-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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