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TAK-683

Name: TAK-683
Brand: TargetMol
SKU: TP2156L
Price: 36 USD
Availability: InStock
Rating: 4.5 (1 reviews)

Catalog No. TP2156LCas No. 872719-49-8

TAK-683 is an effective full KISS1 receptor agonist (IC50=170 pM). TAK-683 is a nonapeptide metastin analog, shows agonistic activities to KISS1R (EC50: 0.96 nM and 1.6 nM for human and rat, respectively).

TAK-683

Catalog No. TP2156LCas No. 872719-49-8

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Product Introduction

Bioactivity

Description	TAK-683 is an effective full KISS1 receptor agonist (IC50=170 pM). TAK-683 is a nonapeptide metastin analog, shows agonistic activities to KISS1R (EC50: 0.96 nM and 1.6 nM for human and rat, respectively).
Targets&IC50	KISS1R:170 pM
In vitro	In rat KISS1R-expressing Chinese hamster ovary cells, TAK-683 exhibits an IC50 value (95% CI) from receptor binding assays is 150-180 pM and EC50 value (95% CI) from Ca+ mobilization assays is 180 (159–203) pM [4].
In vivo	TAK-683 (subcutaneous injection; 0.008, 0.08, 0.8, or 8 μmol/ml/kg; once daily; 7 days) initially increases plasma luteinizing hormone and testosterone levels, but reduces plasma hormones and genital organ weights after 7 days. In a prostate cancer model with TAK-683 (subcutaneous injection; 2.1-21 nmol/kg/day; once daily; 12 weeks), serum PSA concentrations decrease below detection levels (0.5 ng/ml) in all rats by day 14. TAK-683 (subcutaneous injection; 10, 30, or 100 pmol/h; once daily; 4 weeks) shows promise in suppressing reproductive functions and hormone-related diseases such as prostate cancer [3][4].

Chemical Properties

Molecular Weight	1298.45
Formula	C₆₄H₈₃N₁₇O₁₃
Cas No.	872719-49-8

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Keywords

TAK683TAK-683TAK 683