Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).
Description | TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM). |
Targets&IC50 | NAE:0.955 nM |
In vitro | TAS4464 treatment inhibits cullin neddylation. TAS4464 induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines. |
Molecular Weight | 506.51 |
Formula | C21H23FN6O6S |
CAS No. | 1848959-10-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (246.79 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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TAS4464 1848959-10-3 Ubiquitination E1/E2/E3 Enzyme TAS-4464 TAS 4464 inhibitor inhibit