Powder: -20°C for 3 years | In solvent: -80°C for 1 year
THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a polyethylene glycol (PEG) based PROteolysis TArgeting Chimera (PROTAC) linker, employed for the synthesis of PROTAC K-Ras Degrader-1, as documented in reference [1].
Description | THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a polyethylene glycol (PEG) based PROteolysis TArgeting Chimera (PROTAC) linker, employed for the synthesis of PROTAC K-Ras Degrader-1, as documented in reference [1]. |
In vitro | PROTAC K-Ras Degrader-1 is potent?K-Ras?degrader based?PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
Molecular Weight | 477.59 |
Formula | C23H43NO9 |
CAS No. | 2378261-80-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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THP-PEG4-Pyrrolidine(N-Boc)-CH2OH 2378261-80-2 Others THPPEG4Pyrrolidine(NBoc)CH2OH THP-PEG-4-Pyrrolidine(N-Boc)-CH2OH THP PEG4 Pyrrolidine(N Boc) CH2OH inhibitor inhibit