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TIBI

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Catalog No. T28973Cas No. 1196457-06-3

TIBI is an ATP-competitive Rio1 inhibitor that acts in a similar manner to fungamycin and enhances the thermal stability of the enzyme.

TIBI

TIBI

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Purity: 100%
Catalog No. T28973Cas No. 1196457-06-3
TIBI is an ATP-competitive Rio1 inhibitor that acts in a similar manner to fungamycin and enhances the thermal stability of the enzyme.
Pack SizePriceAvailabilityQuantity
2 mg$89In Stock
50 mg$7146-8 weeks
100 mg$1,1406-8 weeks
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Purity:100%
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Product Introduction

Bioactivity
Description
TIBI is an ATP-competitive Rio1 inhibitor that acts in a similar manner to fungamycin and enhances the thermal stability of the enzyme.
Targets&IC50
Rio1:0.09 μM, Rio1:0.05 μM (Ki)
Chemical Properties
Molecular Weight621.72
FormulaC7H2I4N2
Cas No.1196457-06-3
SmilesIC=1C(I)=C(I)C=2NC=NC2C1I
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (48.25 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6084 mL8.0422 mL16.0844 mL80.4221 mL
5 mM0.3217 mL1.6084 mL3.2169 mL16.0844 mL
10 mM0.1608 mL0.8042 mL1.6084 mL8.0422 mL
20 mM0.0804 mL0.4021 mL0.8042 mL4.0211 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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