Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker, useful in the synthesis of PROTACs, as per reference [1].

Thalidomide-O-amido-C8-NH2, referred to as Compound DL7-TL, serves as a degron-linker within the PROTAC framework, covalently connecting to both a degron and a targeting ligand. This configuration enables the degron, a molecule that binds to ubiquitin ligases (e.g., cereblon), to guide the targeting ligand toward specific proteins[1], facilitating their ubiquitination and subsequent degradation.