Thalidomide-O-amido-C8-NH2 hydrochloride is a synthetic conjugate of an E3 ligase ligand-linker, which combines a cereblon ligand derived from Thalidomide and a linker. It can be utilized in the synthesis of PROTACs[1].

Thalidomide-O-amido-C8-NH2 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is covalently bound to at least one degron and at least one targeting ligand, with the degron binding to an ubiquitin ligase (e.g., cereblon), and the targeting ligand binding to the targeted protein(s)[1].