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Tos-PEG3

Catalog No. T17129Cas No. 77544-68-4

Tos-PEG3, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs and 3'-aminooxy oligonucleotide solid supports[1].

Tos-PEG3

Tos-PEG3

Catalog No. T17129Cas No. 77544-68-4
Tos-PEG3, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs and 3'-aminooxy oligonucleotide solid supports[1].
Pack SizePriceAvailabilityQuantity
100 mgInquiry7-10 days
500 mgInquiry7-10 days
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Product Introduction

Bioactivity
Description
Tos-PEG3, a PEG-based PROTAC linker, is suitable for synthesizing PROTACs and 3'-aminooxy oligonucleotide solid supports[1].
In vitro
PROTACs consist of two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other to the target protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Chemical Properties
Molecular Weight304.36
FormulaC13H20O6S
Cas No.77544-68-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (328.56 mM), Sonication and heating are recommended.
H2O: 10 mg/mL (32.86 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM3.2856 mL16.4279 mL32.8558 mL164.2791 mL
5 mM0.6571 mL3.2856 mL6.5712 mL32.8558 mL
10 mM0.3286 mL1.6428 mL3.2856 mL16.4279 mL
20 mM0.1643 mL0.8214 mL1.6428 mL8.2140 mL
DMSO
1mg5mg10mg50mg
50 mM0.0657 mL0.3286 mL0.6571 mL3.2856 mL
100 mM0.0329 mL0.1643 mL0.3286 mL1.6428 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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