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XMD-17-51
🥰Excellent
Catalog No. T22460Cas No. 1628614-50-5
Alias XMD17-51
XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.
XMD-17-51
🥰Excellent
Purity: 99.39%
Catalog No. T22460Alias XMD17-51Cas No. 1628614-50-5
XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock |
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Purity:99.39%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research. |
| In vitro | Overexpression of DCLK1 was found to reduce the antiproliferative effect of XMD-17-51 in the A549 cell line, increasing its IC50 from 27.575 µM to 53.197 µM and vice versa. In a cell-free assay, XMD-17-51 showed an inhibitory effect on DCLK1 kinase activity with an IC50 of 14.64 nM. In non-small cell lung cancer (NSCLC) cell lines, XMD-17-51 also reduced DCLK1 protein expression, which resulted in inhibition of cell proliferation, epithelial-mesenchymal transition (EMT), and stem cell characterization. [1] |
| Alias | XMD17-51 |
| Molecular Weight | 404.47 |
| Formula | C21H24N8O |
| Cas No. | 1628614-50-5 |
| Smiles | O=C1C=2C=CC=CC2N(C3=NC(=NC=C3N1C)NC=4C=NN(C4)C5CCNCC5)C |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 40.00 mg/mL (98.89 mM), Sonication is recommended. DMSO: 40.00 mg/mL (98.89 mM), Sonication is recommended. H2O: 1.00 mg/mL (2.47 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/Ethanol/DMSO
Ethanol/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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