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Z-Asp-CH2-DCB

Catalog No. T13378   CAS 153088-73-4

Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.

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Z-Asp-CH2-DCB Chemical Structure
Z-Asp-CH2-DCB, CAS 153088-73-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 39.00
2 mg In stock $ 48.00
5 mg In stock $ 64.00
10 mg In stock $ 105.00
25 mg In stock $ 176.00
50 mg In stock $ 262.00
1 mL * 10 mM (in DMSO) In stock $ 70.00
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Purity: 99.08%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Z-Asp-CH2-DCB is an irreversible inhibitor of broad spectrum caspase.
In vitro Z-Asp-CH2-DCB (10-100 μM) dose-dependently blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in SEB-stimulated (200 ng) PBMC. Z-Asp-CH2-DCB suppresses the production of the chemokines MCP-1, MIP-1α, and MIP-1β[1]. Z-Asp-CH2-DCB inhibits TSST-1-activated PBMC and reduces IL-1β, IL-6, TNF-α, IFN-γ, MCP-1, MIP-1α, and MIP-1β to 10, 36, 25, 10, 11, 25, and 30%, respectively[1].
In vivo SU5416-induced septal cell apoptosis prevented byZ-Asp-CH2-DCB (1 mg; i.p.; every day for 3 weeks)[1].
Molecular Weight 454.26
Formula C20H17Cl2NO7
CAS No. 153088-73-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95.4mg/mL (210mM), sonification is recommended.

TargetMolReferences and Literature

1. Krakauer T, et al. Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation. Clin Diagn Lab Immunol. 2004 May;11(3):621-4. 2. Kasahara Y, et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest. 2000 Dec;106(11):1311-9. 3. Twumasi P, et al. Caspase inhibitors affect the kinetics and dimensions of tracheary elements in xylogenic Zinnia (Zinnia elegans) cell cultures. BMC Plant Biol. 2010 Aug 6;10:162.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Bioactive Compounds Library Max Covalent Inhibitor Library

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Keywords

Z-Asp-CH2-DCB 153088-73-4 Others ZAspCH2DCB Z Asp CH2 DCB Z-Asp-CH-2-DCB inhibitor inhibit

 

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