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10 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | 5(6)-DiHET is a racemic compound synthesized through the action of epoxide hydrolases on 5(6)-EET, encompassing both enantiomeric forms. It serves as a quantitative marker for 5(6)-EET, facilitating its measurement by utilizing the compound's conversion to 5(6)-δ-lactone in solution. Additionally, 5(6)-DiHET activates large-conductance calcium-activated potassium (KCa1.1/BK) channels in rat small coronary artery smooth muscle cells, supporting its biological significance in vascular regulation. It also acts as a substrate for sheep seminal vesicle COX, leading to the in vitro production of 5,6-dihydroxy prostaglandin E1 and F1α metabolites. Notably, its levels diminish in the plasma of rats subjected to a high-fat diet, indicating a potential role in the pathophysiology of hyperlipidemia. |
Alias | (±)5,6-DiHETrE |
Molecular Weight | 338.5 |
Formula | C20H34O4 |
Cas No. | 213382-49-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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