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αC-Conotoxin PrXA
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Catalog No. T80167
Alias αC-PrXA
αC-Conotoxin PrXA is a neurotoxic paralytic peptide acting as a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), exhibiting inhibitory constants (IC50) of 1.8 nM for the adult α1β1εδ subtype and 3.0 nM for the fetal α1β1γδ subtype. The compound vies with α-bungarotoxin for binding sites at the α/δ and α/γ interfaces of neuromuscular nAChRs, demonstrating high selectivity[1].
αC-Conotoxin PrXA
αC-Conotoxin PrXA
😃Good
Catalog No. T80167Alias αC-PrXA
αC-Conotoxin PrXA is a neurotoxic paralytic peptide acting as a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), exhibiting inhibitory constants (IC50) of 1.8 nM for the adult α1β1εδ subtype and 3.0 nM for the fetal α1β1γδ subtype. The compound vies with α-bungarotoxin for binding sites at the α/δ and α/γ interfaces of neuromuscular nAChRs, demonstrating high selectivity[1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | αC-Conotoxin PrXA is a neurotoxic paralytic peptide acting as a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), exhibiting inhibitory constants (IC50) of 1.8 nM for the adult α1β1εδ subtype and 3.0 nM for the fetal α1β1γδ subtype. The compound vies with α-bungarotoxin for binding sites at the α/δ and α/γ interfaces of neuromuscular nAChRs, demonstrating high selectivity[1]. |
| Alias | αC-PrXA |
| Molecular Weight | 3541.06 |
| Formula | C160H247N43O44S2 |
Storage & Solubility Information
| Storage | keep away from moisture | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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