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[D-Phe2,D-Ala6]-LH-RH

Name: [D-Phe2,D-Ala6]-LH-RH
Brand: TargetMol
SKU: T83498
Rating: 4.5 (1 reviews)

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Catalog No. T83498Cas No. 54784-44-0

Alias Wy 18185

[D-Phe2,D-Ala6]-LH-RH is a potent luteinizing hormone-releasing hormone (LH-RH) antagonist, exhibiting significant activity against LH/FSH-RH and possessing the ability to inhibit ovulation [1].

[D-Phe2,D-Ala6]-LH-RH

😃Good

Catalog No. T83498Alias Wy 18185Cas No. 54784-44-0

[D-Phe2,D-Ala6]-LH-RH is a potent luteinizing hormone-releasing hormone (LH-RH) antagonist, exhibiting significant activity against LH/FSH-RH and possessing the ability to inhibit ovulation [1].

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Product Introduction

Bioactivity

Description	[D-Phe2,D-Ala6]-LH-RH is a potent luteinizing hormone-releasing hormone (LH-RH) antagonist, exhibiting significant activity against LH/FSH-RH and possessing the ability to inhibit ovulation [1].
In vivo	[D-Phe2,D-Ala6]-LH-RH effectively suppresses the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) stimulated by LH-RH in immature male rats [1]. Administered subcutaneously at 1 mg/rat, the compound shows significant anti-ovulatory and contraceptive effects [2]. A single subcutaneous dose at varying concentrations (0.625, 1.25, 2.5 mg/kg) leads to a dose-dependent enhancement of LH-RH activity in the stalk-median eminence (SME) while reducing plasma LH-RH activity in 25-day-old hypophysectomized (hypox) rats [3]. A higher dose of 25 mg/kg, administered subcutaneously, effectively prevents ovulation induced by LRH [4].
Alias	Wy 18185

Chemical Properties

Molecular Weight	1206.35
Formula	C₅₉H₇₉N₁₅O₁₃
Cas No.	54784-44-0

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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