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[Leu144,Arg147]-PLP (139-151)

Catalog No. TP2675Cas No. 188859-65-6

[Leu144,Arg147]-PLP (139-151) is a modified peptide fragment derived from myelin proteolipid protein (PLP), where leucine and arginine have replaced tryptophan and histidine at positions 144 and 147, respectively. This mutant also functions as a T cell receptor (TCR) antagonist, inhibiting the activation of encephalitogenic Th1 clones in vitro. Additionally, [Leu144,Arg147]-PLP (139-151) can impede the progression of experimental autoimmune encephalomyelitis (EAE).

[Leu144,Arg147]-PLP (139-151)
Other Forms of [Leu144,Arg147]-PLP (139-151):
[Leu144, Arg147]-PLP (139-151) TFAT83690
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[Leu144,Arg147]-PLP (139-151)

Catalog No. TP2675Cas No. 188859-65-6
[Leu144,Arg147]-PLP (139-151) is a modified peptide fragment derived from myelin proteolipid protein (PLP), where leucine and arginine have replaced tryptophan and histidine at positions 144 and 147, respectively. This mutant also functions as a T cell receptor (TCR) antagonist, inhibiting the activation of encephalitogenic Th1 clones in vitro. Additionally, [Leu144,Arg147]-PLP (139-151) can impede the progression of experimental autoimmune encephalomyelitis (EAE).
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Product Introduction

Bioactivity
Description
[Leu144,Arg147]-PLP (139-151) is a modified peptide fragment derived from myelin proteolipid protein (PLP), where leucine and arginine have replaced tryptophan and histidine at positions 144 and 147, respectively. This mutant also functions as a T cell receptor (TCR) antagonist, inhibiting the activation of encephalitogenic Th1 clones in vitro. Additionally, [Leu144,Arg147]-PLP (139-151) can impede the progression of experimental autoimmune encephalomyelitis (EAE).
Chemical Properties
Molecular Weight1467.71
FormulaC67H110N20O17
Cas No.188859-65-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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