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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $452 | Backorder | |
5 mg | $1,980 | Backorder |
Description | (S)-5-hydroxy-6-methoxy Duloxetine, an active metabolite of the (S)-duloxetine, functions as a serotonin (5-HT) and norepinephrine reuptake inhibitor. Its formation occurs through the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6 via a 5- or 6-hydroxy duloxetine intermediate, followed by a catechol duloxetine intermediate. This compound effectively inhibits the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) across lipid membranes, with inhibition constants (Kis) of 266, 920, and 2,814 nM, respectively, for human transporters. |
Molecular Weight | 459.51 |
Formula | C19H21NO3S.C4H4O4 |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Solubility Information | Methanol: soluble DMF: soluble Ethanol: soluble DMSO: soluble |
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