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Aβ42-IN-1

Name: Aβ42-IN-1
Brand: TargetMol
SKU: T10211
Rating: 4.5 (1 reviews)

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Catalog No. T10211Cas No. 2582757-69-3

Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ42-IN-1 shows a sustained pharmacokinetic profile.

Aβ42-IN-1

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Catalog No. T10211Cas No. 2582757-69-3

Pack Size	Price	Availability
25 mg	$1,520	10-14 weeks
50 mg	$1,980	10-14 weeks
100 mg	$2,500	10-14 weeks

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Product Introduction

Bioactivity

Description	Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ42-IN-1 shows a sustained pharmacokinetic profile.
Targets&IC50	γ-secretase modulator:0.091 µM
In vivo	Aβ42-IN-1, administered orally at a dosage of 30 mg/kg, exhibits a favorable pharmacokinetic profile in mice and significantly decreases Aβ42 levels in both the brain and plasma by 36% and 66%, respectively. This reduction indicates its efficacy in lowering amyloid-beta peptides, although the brain/plasma ratio of the compound 1v is marginally less than that of 1a [1]. This study was conducted on 8-week-old male ddY mice, highlighting the compound's potential benefits in amyloid-beta related studies.

Chemical Properties

Molecular Weight	499
Formula	C₂₉H₂₇ClN₄O₂
Cas No.	2582757-69-3
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

γ-secretase modulatorAβ42-IN-1Aβ42IN1Aβ42 IN 1Abeta42-IN-1Ab42-IN-1