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AAK1-IN-3

Name: AAK1-IN-3
Brand: TargetMol
SKU: T60829
Rating: 4.5 (1 reviews)

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Catalog No. T60829Cas No. 1802703-20-3

AAK1-IN-3 is a quinoline analogue that can be used in the research of neuropathic pain. AAK1-IN-3 is a brain-penetrant inhibitor of adaptor protein 2-associated kinase 1 (AAK1) (IC 50 = 11 nM) [1].

AAK1-IN-3

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Catalog No. T60829Cas No. 1802703-20-3

AAK1-IN-3 is a quinoline analogue that can be used in the research of neuropathic pain. AAK1-IN-3 is a brain-penetrant inhibitor of adaptor protein 2-associated kinase 1 (AAK1) (IC 50 = 11 nM) [1].

Pack Size	Price	Availability
25 mg	$1,520	8-10 weeks
50 mg	$1,980	8-10 weeks
100 mg	$2,500	8-10 weeks

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Product Introduction

Bioactivity

Description	AAK1-IN-3 is a quinoline analogue that can be used in the research of neuropathic pain. AAK1-IN-3 is a brain-penetrant inhibitor of adaptor protein 2-associated kinase 1 (AAK1) (IC 50 = 11 nM) [1].
In vitro	AAK1-IN-3 (compound (R)-31) is a brain-penetrant kinase inhibitor with a blood/plasma (B/P) ratio of 1.3 [1]. It demonstrates effective inhibition of AAK1 in HEK293 cells, with an IC50 of 108 nM [1].
In vivo	AAK1-IN-3 (compound (R)-31; 30 mg/kg; sc; single dose) reduces μ2 phosphorylation by 46% in C57BL6 mice [1].

Chemical Properties

Molecular Weight	316.4
Formula	C₂₀H₂₀N₄
Cas No.	1802703-20-3

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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