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ABAI-30 is a highly potent and orally bioavailable anti-inflammatory compound that efficiently suppresses nitric oxide (NO) production in lipopolysaccharide (LPS) activated RAW264.7 cells [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | ABAI-30 is a highly potent and orally bioavailable anti-inflammatory compound that efficiently suppresses nitric oxide (NO) production in lipopolysaccharide (LPS) activated RAW264.7 cells [1]. |
In vitro | In RAW264.7 cells, ABAI-30 at concentrations ranging from 10-40 µM suppresses the TLR4-pp65 and NLRP3-caspase-1 signaling pathways, resulting in the decreased expression of IL6, IL-1β, and TNFα at both the transcriptional and translational levels [1]. |
In vivo | In a mouse model of dextran sulfate sodium (DSS)-induced colitis, ABAI-30, administered orally at a dosage of 25 mg/kg for 5 days, exhibited significant in vivo anti-inflammatory effects with no evident toxicity [1]. |
Molecular Weight | 347.33 |
Formula | C17H13N7O2 |
Cas No. | 2757957-25-6 |
Storage | Shipping with blue ice. |
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