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ABBV-303
😃Good
Catalog No. T9901A-054
ABBV-303 is a multispecific NK cell antibody utilizing TriNKET technology to target c-Met for NK cell redirection therapy. It comprises three functional components: a single-chain variable fragment (scFV) targeting c-Met, a Fab arm engaging NKG2D, and an Fc fragment directed at NK cell CD16a [1].
ABBV-303
ABBV-303
😃Good
Catalog No. T9901A-054
ABBV-303 is a multispecific NK cell antibody utilizing TriNKET technology to target c-Met for NK cell redirection therapy. It comprises three functional components: a single-chain variable fragment (scFV) targeting c-Met, a Fab arm engaging NKG2D, and an Fc fragment directed at NK cell CD16a [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ABBV-303 is a multispecific NK cell antibody utilizing TriNKET technology to target c-Met for NK cell redirection therapy. It comprises three functional components: a single-chain variable fragment (scFV) targeting c-Met, a Fab arm engaging NKG2D, and an Fc fragment directed at NK cell CD16a [1]. |
| In vitro | ABBV-303 consists of three functional arms: (1) the single-chain variable fragment (scFV) is derived from ABT-700 and is a common fragment in the c-Met targeting antibody-drug conjugates (ADCs) ABBV-400 and Teliso-V; (2) the Fab arm targets NKG2D, facilitating binding with cells expressing NKG2D, such as NK cells and activated CD8+ T cells; (3) the conventional Fc fragment is an IgG1 Fc heterodimer that targets CD16a on NK cells and connects the other two functional arms of ABBV-303. |
Storage & Solubility Information
| Storage | store at -20°C | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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