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AC260584

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Catalog No. T14092Cas No. 560083-42-3

AC260584 is an allosteric agonist of the M1 muscarinic receptor with a pEC50 of 7.6.

AC260584

AC260584

😃Good
Catalog No. T14092Cas No. 560083-42-3
AC260584 is an allosteric agonist of the M1 muscarinic receptor with a pEC50 of 7.6.
Pack SizePriceAvailabilityQuantity
5 mg310 €6-8 weeks
25 mg1.083 €6-8 weeks
50 mg1.415 €6-8 weeks
100 mg1.890 €6-8 weeks
1 mL x 10 mM (in DMSO)256 €6-8 weeks
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Product Introduction

Bioactivity
Description
AC260584 is an allosteric agonist of the M1 muscarinic receptor with a pEC50 of 7.6.
Targets&IC50
M1:(pEC50)7.6
In vitro
AC260584 is identified as a potent (pEC50=7.6-7.7) and efficacious (90-98% of carbachol) agonist for the muscarinic M1 receptor, exhibiting significant functional selectivity over the M2, M3, M4, and M5 subtypes of muscarinic receptors. This selectivity profile of AC260584 is consistent across native tissues expressing mAChRs and recombinant systems.
In vivo
In rodent studies, AC260584 has been shown to activate the phosphorylation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) in the hippocampus, prefrontal cortex, and perirhinal cortex. This activation is contingent upon the activation of muscarinic M1 receptors, as evidenced by its absence in M1 receptor knockout mice. Furthermore, AC260584 enhances cognitive performance in mice, as demonstrated in the novel object recognition test, with this effect being inhibited by the muscarinic receptor antagonist pirenzepine. Additionally, AC260584 has been noted for its oral bioavailability in rodents. At doses of 3 and 10 mg/kg, AC260584 significantly boosts dopamine release in the medial prefrontal cortex and hippocampus, while only the 10 mg/kg dose notably increases acetylcholine release in these areas.
Chemical Properties
Molecular Weight348.45
FormulaC20H29FN2O2
Cas No.560083-42-3
Relative Density.1.098 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (143.49 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8699 mL14.3493 mL28.6985 mL143.4926 mL
5 mM0.5740 mL2.8699 mL5.7397 mL28.6985 mL
10 mM0.2870 mL1.4349 mL2.8699 mL14.3493 mL
20 mM0.1435 mL0.7175 mL1.4349 mL7.1746 mL
50 mM0.0574 mL0.2870 mL0.5740 mL2.8699 mL
100 mM0.0287 mL0.1435 mL0.2870 mL1.4349 mL

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