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Acid-PEG9-NHS ester

Name: Acid-PEG9-NHS ester
Brand: TargetMol
SKU: T14113
Price: 30 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T14113Cas No. 1895916-27-4

Acid-PEG9-NHS ester is a PEG-based linker for PROTACs [proteolysis-targeting chimeras], facilitating the conjugation of two essential ligands, essential for PROTAC molecule formation, and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Acid-PEG9-NHS ester

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Catalog No. T14113Cas No. 1895916-27-4

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Product Introduction

Bioactivity

Description	Acid-PEG9-NHS ester is a PEG-based linker for PROTACs [proteolysis-targeting chimeras], facilitating the conjugation of two essential ligands, essential for PROTAC molecule formation, and enabling selective protein degradation via the ubiquitin-proteasome system within cells.
In vitro	PROTACs consist of two distinct ligands linked together: one targeting an E3 ubiquitin ligase and the other binding to the target protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Chemical Properties

Molecular Weight	611.63
Formula	C₂₆H₄₅NO₁₅
Cas No.	1895916-27-4
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Acid-PEG9-NHS esterAcidPEG9NHS esterAcid PEG9 NHS esterAcid-PEG-9-NHS ester