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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 8-10 weeks | |
50 mg | $1,980 | 8-10 weeks | |
100 mg | $2,500 | 8-10 weeks |
Description | AD 0261 is a radical scavenger. It has a strong inhibitory action on the generation of lipid peroxides and superoxide anions. |
In vitro | AD 0261 exhibits potent inhibitory activity on lipid peroxide generation (IC50: 0.022 μM) and superoxide anion production (IC50: 0.9-4.0 μM). It dose-dependently inhibits cytokine release/production from PHA-P-stimulated lymphocytes and all lymphocyte activation parameters, achieving 50% inhibition within 1-10 μM. AD 0261 also suppresses ornithine decarboxylase activity (IC50: ~1.0 μM). |
Cell Research | For measurement of [3H]TdR incorporation, cells are incubated for 16 h, and additional (6 h) incubation is carried out in the presence of [3H]TdR (0.5 μCi/well). [3H]TdR incorporation is evaluated in a liquid scintillation counter. IL-2 release from lymphocytes is estimated after 20 h incubation by enzyme immunoassay using the commercially available kits. IL-2 receptor expression is quantitated by flow cytometry using a FITC-labelled monoclonal antibody which recognizes a chain of the IL-2 receptor complex. Cell viability is determined by either the trypan blue exclusion test or propidium iodide staining. |
Molecular Weight | 451.55 |
Formula | C27H31F2N3O |
Cas No. | 145600-69-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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