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Adriforant hydrochloride

Catalog No. T12435Cas No. 2096455-90-0

Adriforant hydrochloride is an antagonist of histamine H4 receptor.

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Pack Size	Price	Availability
25 mg	Inquiry	6-8 weeks
50 mg	Inquiry	6-8 weeks
100 mg	Inquiry	6-8 weeks

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Product Introduction

Bioactivity

Description	Adriforant hydrochloride is an antagonist of histamine H4 receptor.
In vitro	Adriforant in vitro IC50 on human native isolated eosinophils assessing actin polymerisation is 1.16 nM and assuming need 10 times the IC50 for >90% receptor occupancy (and therefore near complete inhibition of the response) suggested a concentration of 12 nM. The data in the whole blood GAFS assay demonstrates that the imetit induced shape change is completely blocked at a total blood concentration of 30 nM (which correcting for PPB and blood partitioning equates to approximately 10 nM free). For the purpose of dose projection and safety margin calculation, a Ceff/Cmin concentration of 10-15 nM is used
Alias	PF-3893787 hydrochloride

Chemical Properties

Molecular Weight	371.74
Formula	C13H25Cl3N6
Cas No.	2096455-90-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (224.16 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6901 mL	13.4503 mL	26.9005 mL	134.5026 mL
5 mM	0.5380 mL	2.6901 mL	5.3801 mL	26.9005 mL
10 mM	0.2690 mL	1.3450 mL	2.6901 mL	13.4503 mL
20 mM	0.1345 mL	0.6725 mL	1.3450 mL	6.7251 mL
50 mM	0.0538 mL	0.2690 mL	0.5380 mL	2.6901 mL
100 mM	0.0269 mL	0.1345 mL	0.2690 mL	1.3450 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc