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ADTN hydrobromide

Name: ADTN hydrobromide
Brand: TargetMol
SKU: T37150
Rating: 4.5 (1 reviews)

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Catalog No. T37150Cas No. 13575-86-5

ADTN hydrobromide (6,7-ADTN) is a dopamine receptor agonist (EC50s = 3.5 and 0.65 μM in rat striatal and nucleus accumbens homogenates, respectively). ADTN hydrobromide stimulates production of cAMP in rat striatal homogenates, a process that is reduced by 70% in the presence of the dopamine antagonist fluphenazine at a concentration of 1 μM.

ADTN hydrobromide

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Catalog No. T37150Cas No. 13575-86-5

Pack Size	Price	Availability
5 mg	$98	35 days
25 mg	$443	35 days
50 mg	$778	35 days

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Product Introduction

Bioactivity

Description	ADTN hydrobromide (6,7-ADTN) is a dopamine receptor agonist (EC50s = 3.5 and 0.65 μM in rat striatal and nucleus accumbens homogenates, respectively). ADTN hydrobromide stimulates production of cAMP in rat striatal homogenates, a process that is reduced by 70% in the presence of the dopamine antagonist fluphenazine at a concentration of 1 μM.
In vivo	In vivo, 6,7-ADTN induces hyperlocomotion in rats when injected bilaterally at a dose of 100 nmol per side into the nucleus accumbens. It increases cAMP production and glycoprotein secretion in the albumen gland of H. duryi (snail). It also reduces sucrose feeding in R. maderae (cockroach) nymphs.

Chemical Properties

Molecular Weight	260.13
Formula	C₁₀H₁₄BrNO₂
Cas No.	13575-86-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 100 mM

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.8442 mL	19.2212 mL	38.4423 mL	192.2116 mL
5 mM	0.7688 mL	3.8442 mL	7.6885 mL	38.4423 mL
10 mM	0.3844 mL	1.9221 mL	3.8442 mL	19.2212 mL
20 mM	0.1922 mL	0.9611 mL	1.9221 mL	9.6106 mL
50 mM	0.0769 mL	0.3844 mL	0.7688 mL	3.8442 mL
100 mM	0.0384 mL	0.1922 mL	0.3844 mL	1.9221 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Keywords

ADTN Hydrobromide(±)2Amino6,7dihydroxy1,2,3,4tetrahydronaphthalene (hydrobromide)(±) 2 Amino 6,7 dihydroxy 1,2,3,4 tetrahydronaphthalene (hydrobromide)