Alcesefoliside has statistically significant cytoprotective activity similar to that of silymarin, tested at 60 ug/mL.

A new flavonol tetraglycoside, quercetin-3-O-[α±-L-rhamnopyranosyl-(1??2)-[α±-L-rhamnopyranosyl-(1??6)]-β-D-galactopyranosyl]-7-O-β-D-glucopyranoside (1), and two new flavonol alkaloids, N-(8-methylquercetin-3-O-[α±-L-rhamnopyranosyl-(1??2)-[α±-L-rhamnopyranosyl-(1??6)]-β-D-galactopyranosyl])-3-hydroxypiperidin-2-one (2) and N-(8-methylkaempferol-3-O-[α±-L-rhamnopyranosyl-(1??2)-[α±-L-rhamnopyranosyl-(1??6)]-β-D-galactopyranosyl])-3-hydroxypiperidin-2-one (3), were isolated from the aerial parts of Astragalus monspessulanus ssp. monspessulanus. Two rare flavonoids with an unusual 3-hydroxy-3-methylglutaric acid moiety, quercetin-3-O-α±-L-rhamnopyranosyl-(1??2)-[6-O-(3-hydroxy-3-methylglutaryl)-β-D-galactopyranoside (4) and kaempferol-3-O-α±-L-rhamnopyranosyl-(1??2)-[6-O-(3-hydroxy-3-methylglutaryl)-β-D-galactopyranoside (5), were isolated from the aerial parts of A. monspessulanus ssp. illyricus. In addition, the eight known flavonoids alangiflavoside (6), Alcesefoliside (7), mauritianin (8), quercetin-3-β-robinobioside (9), cosmosine (10), apigenin-4'-O-glucoside (11), trifolin (12), and rutin (13) were isolated from aerial parts of A. monspessulanus ssp. monspessulanus. Their structures were elucidated via NMR and HRESIMS data.