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Aldosterone

Catalog No. T19186Cas No. 52-39-1

Aldosterone, the primary mineralocorticoid, is synthesized and secreted by the zona glomerulosa of the adrenal cortex in response to activation of the renin-angiotensin system or high dietary potassium.

Aldosterone

Aldosterone

Purity: 99%
Catalog No. T19186Cas No. 52-39-1
Aldosterone, the primary mineralocorticoid, is synthesized and secreted by the zona glomerulosa of the adrenal cortex in response to activation of the renin-angiotensin system or high dietary potassium.
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Product Introduction

Bioactivity
Description
Aldosterone, the primary mineralocorticoid, is synthesized and secreted by the zona glomerulosa of the adrenal cortex in response to activation of the renin-angiotensin system or high dietary potassium.
In vitro
Aldosterone (1-1000 nM; 24 hours) dose-dependently inhibits interleukin-1β-stimulated nitrite production in vascular smooth muscle cells [3].
In vivo
Aldosterone (1 mg/Kg+1% NaCl; i.h.; once daily for 3 weeks) significantly increases systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular systolic pressure (LVSP), and left ventricular end-diastolic pressure (LVEDP) [4]. Aldosterone (0.72 mg/kg/day; 14 days) causes a small increase (14 mmHg) in blood pressure in male mice [5].
Chemical Properties
Molecular Weight360.44
FormulaC21H28O5
Cas No.52-39-1
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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