Allo-aca TFA, a potent and specific leptin receptor antagonist peptide, inhibits leptin signaling and function across various in vitro and in vivo models [1] [2].

Allo-aca TFA impedes the leptin-stimulated growth of MDA-MB-231 cells at a 50 pM concentration.

In an MDA-MB-231 orthotopic mouse xenograft model, subcutaneous administration of Allo-aca TFA significantly extended mean survival time from 15.4 days in untreated controls to 24 days and 28.1 days at dosages of 0.1 mg/kg/day and 1 mg/kg/day, respectively [1].