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ALV1

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Catalog No. T63339Cas No. 2438124-79-7

ALV1 is a potent degradation agent of Ikaros and Helios, with similar degradation activity against IKZF1/2/3. ALV1 significantly reduced the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal protein RPL4, and induced Helios/CRBN dimerization, which promoted IL-2 secretion.

ALV1

ALV1

😃Good
Catalog No. T63339Cas No. 2438124-79-7
ALV1 is a potent degradation agent of Ikaros and Helios, with similar degradation activity against IKZF1/2/3. ALV1 significantly reduced the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal protein RPL4, and induced Helios/CRBN dimerization, which promoted IL-2 secretion.
Pack SizePriceAvailabilityQuantity
25 mg$1,0506-8 weeks
50 mg$1,3646-8 weeks
100 mg$1,9966-8 weeks
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Product Introduction

Bioactivity
Description
ALV1 is a potent degradation agent of Ikaros and Helios, with similar degradation activity against IKZF1/2/3. ALV1 significantly reduced the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal protein RPL4, and induced Helios/CRBN dimerization, which promoted IL-2 secretion.
Chemical Properties
Molecular Weight494.93
FormulaC25H23ClN4O5
Cas No.2438124-79-7
Storage & Solubility Information
StorageShipping with blue ice.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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