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ALV2

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ALV2

Catalog No. T40099Cas No. 2438124-95-7

ALV2 is a potent and selective Helios degrader that binds to CRBN protein, with an IC50 of 0.57 μM. Helios, a zinc-finger transcription factor, is essential for maintaining a stable T reg cell phenotype in the inflammatory tumor microenvironment.

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Product Introduction

Bioactivity

Description	ALV2 is a potent and selective Helios degrader that binds to CRBN protein, with an IC50 of 0.57 μM. Helios, a zinc-finger transcription factor, is essential for maintaining a stable T reg cell phenotype in the inflammatory tumor microenvironment.
Targets&IC50	CRBN:0.57 μM (IC50)
In vitro	ALV2, within a concentration range of 10 nM to 100 μM, initiates CRBN-Helios dimerization as evidenced by the TR-FRET assay[1]. At lower concentrations (0.1-10 μM), ALV2 specifically facilitates the degradation of Helios in Jurkat cells[1]. Moreover, when pre-administered for 18 hours at a concentration of 1 μM, ALV2 enhances IL-2 secretion in Jurkat cells[1].
In vivo	ALV2, administered intraperitoneally at a dosage of 100 mg/kg twice daily for 7 days, selectively induces Helios degradation in vivo in Crbn I391V/I391V mouse models. This treatment specifically reduced Helios levels without affecting Ikaros in splenic CD4 + FoxP3 + T regulatory cells.

Chemical Properties

Molecular Weight	523.97
Formula	C26H26ClN5O5
Cas No.	2438124-95-7

Storage & Solubility Information

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Keywords

ALV 2ALV-2ALV2