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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,400 | 6-8 weeks | |
50 mg | $1,820 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | AM6538 is a long-acting, high affinity, and pseudo-irreversible cannabinoid antagonist, structurally analogous to rimonabant. It serves as a valuable tool for assessing the apparent efficacy of cannabinoid partial and full agonists. Additionally, AM6538 holds potential for future investigations that necessitate temporary reductions in cannabinoid receptor availability[1]. |
In vitro | AM6538 acts as a cannabinoid antagonist, targeting CB1 receptors within HEK-293 cells, exhibiting wash-resistant binding properties[1]. |
In vivo | AM6538 (1~10 mg/kg) effectively antagonizes the antinociceptive effects of cannabinoid agonists in mice[1], with a dosage of 10 mg/kg indicating partial recovery of AM4054 effects. It decreases the tau values for all cannabinoid agonists in a dose-dependent manner, indicating reduced receptor availability. Notably, AM6538 exerts a lasting antagonism, significantly affecting the tetrahydrocannabinol dose-effect function, observable up to 7 days post-treatment[1]. |
Molecular Weight | 542.41 |
Formula | C26H25Cl2N5O4 |
Cas No. | 1245626-00-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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