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Description | Amino-PEG5-CH2COOH is a PEG-based linker for PROTACs, joining two essential ligands to form PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells (PROTACs) [ubiquitin-proteasome system]. |
In vitro | PROTACs consist of two ligands, one binding to an E3 ubiquitin ligase and the other to the target protein, connected by a linker. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1]. |
Molecular Weight | 295.33 |
Formula | C12H25NO7 |
Cas No. | 141282-35-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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