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Anabaseine is a non-selective nicotinic agonist that stimulates all alpha-7 subtypes of AChRs, with a preference for those in skeletal muscle and the brain. Additionally, it acts as a weak partial agonist at alpha-4 beta-2 [nAChRs].
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Description | Anabaseine is a non-selective nicotinic agonist that stimulates all alpha-7 subtypes of AChRs, with a preference for those in skeletal muscle and the brain. Additionally, it acts as a weak partial agonist at alpha-4 beta-2 [nAChRs]. |
In vitro | Anabaseine serves as a full agonist at the α7 AChR within the central nervous system (CNS) and operates as a full agonist for α1β1?δ and α1β1γδ (Torpedo) receptors in the peripheral nervous system. Additionally, it functions as a neuromuscular agonist on the frog rectus abdominis muscle, demonstrating efficacy within a range of EC 50 values from 0.25 to 0.74 μM. |
In vivo | Anabaseine (3.6 μmol/kg; subcutaneous injection) elevates ACh levels [1]. |
Molecular Weight | 160.22 |
Formula | C10H12N2 |
Cas No. | 3471-05-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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